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. 2012 Jun 1;13(2):79-84.
doi: 10.5152/jtgga.2012.08. eCollection 2012.

Total and lipid bound sialic acid levels in patients with polycystic ovary syndrome

Ali Ozcan  1 , Aykan Yücel  1 , Volkan Noyan  1 , Nevin Sağsöz  1 , Osman Cağlayan  2
Affiliations

Total and lipid bound sialic acid levels in patients with polycystic ovary syndrome

Ali Ozcan et al. J Turk Ger Gynecol Assoc. .

Abstract
in English, Turkish

Objective: To evaluate serum total and lipid bound sialic acid (TSA&LBSA) levels in patients with polycystic ovary syndrome (PCOS).

Material and methods: Forty women with PCOS and 35 healthy controls were enrolled in the study. Serum TSA, LBSA, follicle stimulating hormone, lutenizing hormone, estradiol, thyroid stimulating hormone, prolactin, dehydroepiandrosterone sulphate, androstenedione, free testosterone, total testosterone, 17-OH progesterone, sex hormone binding globulin, cortisol, total cholesterol, triglyceride, high density lipoprotein and low density lipoprotein were measured in each subject. Insulin resistance was estimated by fasting insulin level, fasting glucose: insulin ratio and 75-g glucose tolerance test for 2 hours.

Results: Serum TSA levels were not significantly different between the groups. Serum LBSA levels were higher in patients with PCOS compared to the control group. TSA was correlated with androstenedione and HOMA-IR in the PCOS group. Positive correlations were found between LBSA and dehydroepiandrosterone sulphate in patients with PCOS. After correction for BMI, the only existing significant correlation was between LBSA and follicle stimulating hormone.

Conclusion: Serum LBSA levels, which has previously been found to be higher in cardiovascular diseases and diabetes mellitus, are elevated in PCOS.

Amaç: Polikistik over sendromlu hastalarda (PKOS) serum total ve lipid bağlı sialik asit (TSA&LBSA) düzeylerinin değerlendirilmesi.

Gereç ve yöntemler: Çalışmaya kırk PKOS’lu hasta ve 35 sağlıklı kontrol dahil edildi. Her olguda serumda TSA, LBSA, folikül stimülan hormon, luteinizan hormon, östradiol, tiroid stimülan hormon, prolaktin, dehidroepiandrosteron sülfat, androstenedion, serbest testosteron, total testosteron, 17-OH progesteron, seks hormon bağlayıcı globulin, kortizol, total kolesterol, trigliserid, yüksek densiteli lipoprotein ve düşük densiteli lipoprotein ölçüldü. Açlık insülin seviyesi, açlık glükozu/insülin oranı ve 2 saatlik 75-g glükoz tolerans testi ile insülin rezistansı değerlendirildi.

Bulgular: Serum TSA seviyeleri açısından gruplar arasında anlamlı fark yoktu. Kontrol grubuna göre karşılaştırıldığında PKOS’lu hastalarda serum LBSA seviyeleri yüksekti. PKOS grubunda TSA, androstenedione ve HOMA-IR ile korele bulundu. PKOS’lu hastalarda LBSA ile dehidroepiandrosteron sulfat arasında pozitif korelasyon bulundu. BMI’ya göre düzeltme sonrası, kalan tek anlamlı korelasyon LBSA ile folikül stimülan hormon arasında idi.

Sonuç: Kardiyovasküler hastalıklarda ve diabette arttığı bilinen LBSA’nın serum seviyeleri PKOS’da yükselir.

Keywords: Polycystic ovary syndrome; lipid bound sialic acid; risk; total sialic acid.

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Figures

Figure 1
Figure 1
Serum total sialic acid and lipid bound sialic acid levels in patients with PCOS and the controls
See this image and copyright information in PMC

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References

    1. Carmina E, Lobo RA. Do hyperandrogenic women with normal menses have polycystic ovary syndrome? Fertil Steril. 1999;71:319–22. - PubMed
    1. Wild RA, Painter PC, Coulson PB, Carruth KB, Ranney GB. Lipoprotein lipid concentrations and cardiovascular risk in women with polycystic ovary syndrome. J Clin End Met. 1985;61:946–51. - PubMed
    1. Hopkinson EC, Satar N, Fleming R, Greer IA. Polycsytic ovary syndrome: the metabolic syndrome comes to gynecology. BMJ. 1998;317:329–32. - PMC - PubMed
    1. Cook GM. Techniques for the analysis of membrane carbohydrates. In: Maddy AH, editor. Biochemical analysis of membranes. 1st ed. London: Wiley & Sons; 1976. pp. 287–92.
    1. Schauer R. Chemistry, metabolism and biological function of sialic acids. Adv Carbohydr Chem Biochem. 1982;40:131–234. - PubMed