Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2013 Mar 1;14(1):48-9.
doi: 10.5152/jtgga.2013.11. eCollection 2013.

Case report: Methotrexate-induced pericardial effusion

Betül Dündar  1 , Alper Karalök  1 , Işın Ureyen  1 , Burcu Gündoğdu  1 , Reyhan Oçalan  1 , Taner Turan  1 , Nurettin Boran  1 , Gökhan Tulunay  1 , M Faruk Köse  1
Affiliations

Case report: Methotrexate-induced pericardial effusion

Betül Dündar et al. J Turk Ger Gynecol Assoc. .

Abstract
in English, Turkish

We report a case of pericardial effusion induced by methotrexate in a patient with low risk gestational trophoblastic neoplasia, who had been taking the first course of sequential methotrexate-folinic acid treatment. After aspiration of pericardial effusion another methotrexate-folinic acid course was given and the pericardial effusion did not relapse.

Ardışık metotreksat-folinik asit tedavisi verilen düşük riskli gestasyonel trofoblastik neoplazi olgusunda ilk kemoterapi kürü sonrasında perikardiyal efüzyon gelişti. Perikardiyal efüzyon aspire edildikten sonra ikinci kür kemoterapi verildi ve olgumuzda perikardiyal efüzyonun tekrar etmediği gözlendi.

Keywords: Methotrexate; gestational trophoblastic neoplasia; pericardial effusion; toxicity; treatment.

PubMed Disclaimer

References

    1. Lurain JR, Elfstrand EP. Single-agent methotrexate chemotherapy for the treatment of nonmetastatic gestational trophoblastic tumors. Am J Obstet Gynecol. 1995;172:574–9. doi: 10.1016/0002-9378(95)90575-8. - DOI - PubMed
    1. Berkowitz RS, Goldstein DP, Bernstein MR. Ten year’s experience with methotrexate and folinic acid as primary therapy for gestational trophoblastic disease. Gynecol Oncol. 1986;23:111–8. doi: 10.1016/0090-8258(86)90123-X. - DOI - PubMed
    1. Akoun GM, Gauthier-Rahman S, Mayaud CM, Touboul JL, Denis MF. Leukocyte migration inhibition in methotrexate-induced pneumonitis. Evidence for an immunologic cell-mediated mechanism. Chest. 1987;91:96–9. doi: 10.1378/chest.91.1.96. - DOI - PubMed
    1. White DA, Rankin JA, Stover DE, Gellene RA, Gupta S. Methotrexate pneumonitis. Bronchoalveolar lavage findings suggest an immunologic disorder. Am Rev Respir Dis. 1989;139:18–21. doi: 10.1164/ajrccm/139.1.18. - DOI - PubMed
    1. Massin F, Coudert B, Marot JP, Foucher P, Camus P, Jeannin L. Pneumopathy caused by methotrexate. Rev Mol Respir. 1990;7:5–15. - PubMed

LinkOut - more resources