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. 2013 Jun 1;14(2):81-6.
doi: 10.5152/jtgga.2013.53179. eCollection 2013.

Melatonin treatment results in regression of endometriotic lesions in an ooferectomized rat endometriosis model

Nilüfer Çetinkaya Kocadal  1 , Rukset Attar  1 , Gazi Yıldırım  1 , Cem Fıçıcıoğlu  1 , Ferda Ozkan  2 , Bayram Yılmaz  3 , Narter Yesildaglar  1
Affiliations

Melatonin treatment results in regression of endometriotic lesions in an ooferectomized rat endometriosis model

Nilüfer Çetinkaya Kocadal et al. J Turk Ger Gynecol Assoc. .

Abstract
in English, Turkish

Objective: We aimed to determine the effects of melatonin treatment on endometrial implants in an oopherectomized rat endometriosis model.

Material and methods: This study is a prospective, randomised, controlled experimental study. It was carried out at the Experimental Research Center of Yeditepe University (YUDETAM). Twenty-two, female, non-pregnant, nulligravid Spraque-Dawley albino rats were included in our study. Endometriosis was surgically induced in oopherectomized rats. Rats were randomised into two groups: control group and melatonin group. In the melatonin group, rats were treated with melatonin (20 mg/kg/day) for two weeks. After the operations were performed to assess the regression of the endometriotic lesions, melatonin treatment was stopped. At the end of the sixth week necropsies were performed to assess the rate of recurrence. The volume and histopathological scores of endometriotic foci were examined.

Results: Volumes of the endometriotic lesions significantly decreased in the melatonin group. Also, when the melatonin group was analysed within itself, endometriotic lesion volumes decreased and histopathological scores increased significantly.

Conclusion: Melatonin causes regression of the endometriotic lesions in rats and improvement in their histopathological scores.

Amaç: Ooferektomize sıçan endometriozis modelinde melatoninin endometriotik odaklar üzerine etkisini incelemeyi amaçladık.

Gereç ve yöntemler: Bu çalışma prospektif, randomize, kontrollü, deneysel bir çalışmadır. Çalışma Yeditepe Üniversitesi Deneysel Araştırma Merkezinde (YÜDETAM) yapıldı. Deneysel çalışmamıza 22 adet dişi, gebe olmayan, nulligravid Spraque-Dawley albino sıçan dahil edildi. Ooferektomize edilen sıçanlarda cerrahi olarak endometriozis oluşturuldu. Sıçanlar iki gruba ayrıldı: kontrol grubu ve melatonin grubu. Melatonin grubunda 2 hafta boyunca sıçanlara melatonin (20 mg/kg/gün) tedavisi verildi. Endometriotik regresyonu değerlendirmek için operasyonlar yapıldıktan sonra melatonin tedavisi sonlandırıldı. Rekürrens oranlarını değerlendirmek için altıncı haftanın sonunda nekropsiler yapıldı. Endometriotik odakların hacim ve histopatolojik skorları değerlendirildi.

Bulgular: Endometriotik lezyonların hacimleri melatonin grubunda anlamlı derecede azaldı. Ayrıca, melatonin grubu kendi içerisinde incelendiğinde endometriotik lezyonların hacimlerinin anlamlı derecede azaldı ve histopatolojik skorları anlamlı derecede arttı.

Sonuç: Melatonin sıçanlarda endometriotik odakların gerilemesine ve histopatolojik skorların iyileşmesine neden olur.

Keywords: Endometriosis; histopathological score; melatonin; oopherectomized rats; volume.

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