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. 2013 Dec 1;14(4):210-5.
doi: 10.5152/jtgga.2013.55452. eCollection 2013.

Evaluation of mean platelet volume, neutrophil/lymphocyte ratio and platelet/lymphocyte ratio in advanced stage endometriosis with endometrioma

Ali Yavuzcan  1 , Mete Cağlar  1 , Yusuf Ustün  1 , Serdar Dilbaz  1 , Ismail Ozdemir  2 , Elif Yıldız  1 , Atilla Ozkara  1 , Selahattin Kumru  1
Affiliations

Evaluation of mean platelet volume, neutrophil/lymphocyte ratio and platelet/lymphocyte ratio in advanced stage endometriosis with endometrioma

Ali Yavuzcan et al. J Turk Ger Gynecol Assoc. .

Abstract
in English, Turkish

Objective: We compared the preoperative values of mean platelet volume (MPV) and peripheral systemic inflammatory response (SIR) markers (neutrophil/lymphocyte ratio and platelet/lymphocyte ratio) between patients with advanced-stage (stage 3/4) endometriosis having endometrioma (OMA) and patients with a non-neoplastic adnexal mass other than endometrioma (non-OMA).

Material and methods: Patients who underwent operations with the pre-diagnosis of infertility or adnexal mass and who underwent laparoscopic tubal ligation were included.

Results: Haemoglobin levels, leucocyte count, platelet count, neutrophil count and lymphocyte count were not significantly different between patients with advanced stage endometriosis having OMA, patients with non-OMA and patients in the control group (p=0.970, p=0.902, p=0.373, p=0.501 and p=0.463, respectively). Patients with stage 3/4 endometriosis having OMA, patients with non-OMA and control patients were also not significantly different in terms of MPV (p=0.836), neutrophil/lymphocyte ratio (NLR) (p=0.555) and platelet/lymphocyte ratio (PLR) (p=0.358). Preoperative cancer antigen 125 (Ca-125) levels were significantly higher in patients with OMA (p=0.006). Mean size of the OMAs was significantly lower than non-OMAs (p=0.000).

Conclusion: It is very important to determine advanced stage endometriosis and OMAs during preoperative evaluation in order to inform patients and plan an appropriate surgical approach. We demonstrate that MPV, NLR and PLR values are not useful for this purpose in patients with advanced stage endometriosis that are proven to develop severe inflammation at either the cellular or molecular level.

Amaç: Biz endometrioma bulunan ileri evre endometriozise sahip hastalar (evre 3/4) ve endometrioma dışı non-neoplastik adneksiyel kitle bulunan hastalar arasında preoperatif ortalama trombosit hacmi (MPV) ve periferik sistemik inflamatuvar yanıt (SIR) belirteçlerinin (nötrofil/lenfosit oranı ve lenfosit/trombosit oranı) değerlerini karşılaştırdık.

Gereç ve yöntemler: İnfertilite veya adneksiyel kitle ön tanısı ile opere edilen hastalar ile laparaskopik bilateral tubal ligasyon yapılan hastalar çalışmaya dahil edilmiştir.

Bulgular: Hemoglobin düzeyi, lökosit sayısı, trombosit sayısı, nötrofil sayısı ve lenfosit sayısı açısından endometrioma saptanan ileri evre endometriosis hastaları (evre 3/4), endometrioma dışı adneksiyel kitle saptanan ve kontrol grubu hastaları arasında anlamlı farklılık saptanmamıştır (p=0.970, p=0.902, p=0.373, p=0.501 ve p=0.463; sırasıyla). Endometrioma saptanan ileri evre endometriosis hastaları (evre 3/4), endometrioma dışı adneksiyel kitle saptanan ve kontrol grubu hastaları arasında aynı zamanda MPV (p=0.836), nötrofil/lenfosit oranı (NLR) (p=0.555) ve lenfosit/trombosit oranı (PLR) (p=0.358) açısından istatistiksel olarak anlamlı farklılık tespit edilmemiştir. Ameliyat öncesi kanser antijen 125 (Ca 125) seviyeleri operasyonda endometrioma saptanan (p=0.006) hastalarda anlamlı olarak yüksek bulunmuştur. Endometriomaların ortalama boyutu endometrioma dışı kitlelere göre daha düşük tespit edilmiştir (p=0.000).

Sonuç: İleri evre endometriozis ve endometrioma bulunan hastaları preoperatif değerlendirme sırasında belirlemek; hastayı bilgilendirmek ve uygun cerrahi yaklaşımı planlamak için çok önemlidir. Bu çalışmada MPV, NLR ve PLR değerlerininin hücresel veya moleküler düzeyde şiddetli inflamasyon varlığı kanıtlanmış olan ileri evre endometriozis hastalarında bu amaç için yararlı olmadığını gösterilmiştir.

Keywords: Endometriosis; mean platelet volume; neutrophil/lymphocyte ratio; platelet/lymphocyte ratio.

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