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Case Reports
. 2014 Jan 9:3:26.
doi: 10.4103/2277-9175.124672. eCollection 2014.

Streptomyces infection in Cushing syndrome: A case report and literature review

Masoud Ataiekhorasgani  1 , Nasim Jafaripozve  2 , Omid Zaerin  1
Affiliations
Case Reports

Streptomyces infection in Cushing syndrome: A case report and literature review

Masoud Ataiekhorasgani et al. Adv Biomed Res. .

Abstract

Streptomyces are saprophytic soil organisms rarely known to cause invasive infections. Streptomyces is the largest genus, producing antibacterial, antifungal and antiparasitic drugs. The case was a 24-year-old man, admitted for sudden dyspnea, fever and sputum and decreased sound in the left lung. The chest X-ray showed hydropneumothorax. After chest tube insertion, lung expansion did not happen. Pleural effusion was exudative with gram-positive bacillus and Streptomyces in culture. Owing to symptoms of Cushing in history, examination and laboratory work-up for Cushing was done and finally he underwent bilateral adrenalectomy. The patient was on antibiotic broad spectrum antibiotic and then was changed to antibiotic as organism was sensitive to and discharged with clarithromycin for 6 months. Streptomyces happens in immunodeficient patient. Diagnosis is based on culture and contamination was ruled out. Treatment period is longer for patients owing to slow growing nature.

Keywords: Cushing syndrome; Streptomyces; pulmonary infection.

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Conflict of interest statement

Conflict of Interest: None declared.

Figures

Figure 1
Figure 1
Chest X-ray showed hydropneumothorax
Figure 2
Figure 2
Chest computed tomography scans showed pneumothorax
Figure 3
Figure 3
Computed tomography scan shows pleural thickening
Figure 4
Figure 4
chest X-ray shows persistent pneumothorax after chest tube insertion
Figure 5
Figure 5
fibrin deposition and chronic inflammatory cell infiltration, with chronic inflammation
Figure 6
Figure 6
Adrenal hyperplasia without malignancy
See this image and copyright information in PMC

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