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Case Reports
. 2014 Jan 9:3:29.
doi: 10.4103/2277-9175.124679. eCollection 2014.

Inflammatory pseudotumor of spleen

Parvin Rajabi  1 , Hasan Noorollahi  2 , Mohsen Hani  1 , Marzie Bagheri  1
Affiliations
Case Reports

Inflammatory pseudotumor of spleen

Parvin Rajabi et al. Adv Biomed Res. .

Abstract

Inflammatory pseudotumor (IPT) is an uncommon tumor and its occurrence in spleen is rare. This tumor is composed of proliferation of spindle cells of unknown origin and etiology that mimic other tumors at clinical and histological evaluation. The most surmising etiology is Epstein Barr virus (EBV) and the most suspected origin is myofibroblasts, hence its synonym is "inflammatory myofibroblastic tumor." The clinical appearance of tumor is related to its location but the most ones are abdominal pain, fever and weight loss. Surgical removal for this lesion is treatment of choice and there is few reported case with recurrence and metastasis. Herein we report a 63-year-old female patient with and abdominal discomfort that primary paraclinical investigations had been showed splenic mass and therefore surgical treatment was performed for her. Microscopic examination suggest some different diagnosis such as IPT, thus immunohistochemical staining was perform to confirm the diagnosis and rule out the others.

Keywords: Immunohistochemical staining; inflammatory pseudotumor; spleen.

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Conflict of interest statement

Conflict of Interest: None declared.

Figures

Figure 1
Figure 1
Hypodense splenic mass
Figure 2
Figure 2
Well circumscribed bulging brown colored mass
Figure 3
Figure 3
Diffuse infiltration of fibroblasts and inflammatory cells
Figure 4
Figure 4
Anaplastic lymphoma kinase 1 is negative in myofibroblastic cells
See this image and copyright information in PMC

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