Cumulative ultraviolet radiation flux in adulthood and risk of incident skin cancers in women

doi:10.1038/bjc.2014.43

. 2014 Apr 2;110(7):1855-61.

doi: 10.1038/bjc.2014.43. Epub 2014 Mar 4.

Cumulative ultraviolet radiation flux in adulthood and risk of incident skin cancers in women

S Wu¹, J Han², R A Vleugels¹, R Puett³, F Laden⁴, D J Hunter⁵, A A Qureshi⁶

Affiliations

¹ Department of Dermatology, Brigham and Women's Hospital and Harvard Medical School, 45 Francis Street, 221L, Boston, MA 02115, USA.
² 1] Department of Dermatology, Brigham and Women's Hospital and Harvard Medical School, 45 Francis Street, 221L, Boston, MA 02115, USA [2] Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA [3] Department of Epidemiology, Fairbanks School of Public Health, Simon Cancer Center, Indiana University, Indianapolis, IN 46202, USA [4] Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA.
³ Maryland Institute of Applied Environmental Health, College Park, College Park, MD 20742, USA.
⁴ 1] Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA [2] Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA [3] Exposure, Epidemiology and Risk Program, Department of Environmental Health, Harvard School of Public Health, Boston, MA 02115, USA.
⁵ 1] Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA [2] Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA.
⁶ 1] Department of Dermatology, Brigham and Women's Hospital and Harvard Medical School, 45 Francis Street, 221L, Boston, MA 02115, USA [2] Department of Dermatology, Warren Alpert Medical School, Brown University, Providence, RI 02903, USA.

PMID: 24595003
PMCID: PMC3974077
DOI: 10.1038/bjc.2014.43

Cumulative ultraviolet radiation flux in adulthood and risk of incident skin cancers in women

S Wu et al. Br J Cancer. 2014.

. 2014 Apr 2;110(7):1855-61.

doi: 10.1038/bjc.2014.43. Epub 2014 Mar 4.

Authors

S Wu¹, J Han², R A Vleugels¹, R Puett³, F Laden⁴, D J Hunter⁵, A A Qureshi⁶

Affiliations

¹ Department of Dermatology, Brigham and Women's Hospital and Harvard Medical School, 45 Francis Street, 221L, Boston, MA 02115, USA.
² 1] Department of Dermatology, Brigham and Women's Hospital and Harvard Medical School, 45 Francis Street, 221L, Boston, MA 02115, USA [2] Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA [3] Department of Epidemiology, Fairbanks School of Public Health, Simon Cancer Center, Indiana University, Indianapolis, IN 46202, USA [4] Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA.
³ Maryland Institute of Applied Environmental Health, College Park, College Park, MD 20742, USA.
⁴ 1] Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA [2] Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA [3] Exposure, Epidemiology and Risk Program, Department of Environmental Health, Harvard School of Public Health, Boston, MA 02115, USA.
⁵ 1] Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA [2] Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA.
⁶ 1] Department of Dermatology, Brigham and Women's Hospital and Harvard Medical School, 45 Francis Street, 221L, Boston, MA 02115, USA [2] Department of Dermatology, Warren Alpert Medical School, Brown University, Providence, RI 02903, USA.

PMID: 24595003
PMCID: PMC3974077
DOI: 10.1038/bjc.2014.43

Abstract

Background: Solar ultraviolet (UV) exposure estimated based on residential history has been used as a sun exposure indicator in previous case-control and descriptive studies. However, the associations of cumulative UV exposure based on residential history with different skin cancers, including melanoma, squamous cell carcinoma (SCC), and basal cell carcinoma (BCC), have not been evaluated simultaneously in prospective studies.

Methods: We conducted a cohort study among 108,578 women in the Nurses' Health Study (1976-2006) to evaluate the relative risks of skin cancers with cumulative UV flux based on residential history in adulthood.

Results: Risk of SCC and BCC was significantly lower for women in lower quintiles vs the highest quintile of cumulative UV flux (both P for trend <0.0001). The association between cumulative UV flux and risk of melanoma did not reach statistical significance. However, risk of melanoma appeared to be lower among women in lower quintiles vs the highest quintile of cumulative UV flux in lag analyses with 2-10 years between exposure and outcome. The multivariable-adjusted hazard ratios per 200 × 10(-4) Robertson-Berger units increase in cumulative UV flux were 0.979 (95% confidence interval (CI): 0.933, 1.028) for melanoma, 1.072 (95% CI: 1.041, 1.103) for SCC, and 1.043 (95% CI: 1.034, 1.052) for BCC.

Conclusions: Associations with cumulative UV exposure in adulthood among women differed for melanoma, SCC, and BCC, suggesting a potential variable role of UV radiation in adulthood in the carcinogenesis of the three major skin cancers.

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References

1. Almahroos M, Kurban AK.2004Ultraviolet carcinogenesis in nonmelanoma skin cancer. Part I: incidence rates in relation to geographic locations and in migrant populations Skinmed 329–35.quiz35-36. - PubMed
1. Arkema EV, Hart JE, Bertrand KA, Laden F, Grodstein F, Rosner BA, Karlson EW, Costenbader KH. Exposure to ultraviolet-B and risk of developing rheumatoid arthritis among women in the Nurses' Health Study. Ann Rheum Dis. 2013;72:506–511. - PMC - PubMed
1. Blunden A, Lower T, Slevin T. Knowledge, awareness, and use of the UV index amongst the West Australian public. J Health Commun. 2004;9:207–221. - PubMed
1. Boni R, Schuster C, Nehrhoff B, Burg G. Epidemiology of skin cancer. Neuroendocrinol Lett. 2002;23 (Suppl 2:48–51. - PubMed
1. Brooks KR, Brooks DR, Hufford D, Samenow J, Geller AC. Are television stations and weather pages still reporting the UV index? A national media follow-up study. Arch Dermatol. 2005;141:526. - PubMed

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[1] Almahroos M, Kurban AK.2004Ultraviolet carcinogenesis in nonmelanoma skin cancer. Part I: incidence rates in relation to geographic locations and in migrant populations Skinmed 329–35.quiz35-36. - PubMed

[2] Almahroos M, Kurban AK.2004Ultraviolet carcinogenesis in nonmelanoma skin cancer. Part I: incidence rates in relation to geographic locations and in migrant populations Skinmed 329–35.quiz35-36. - PubMed

[3] Arkema EV, Hart JE, Bertrand KA, Laden F, Grodstein F, Rosner BA, Karlson EW, Costenbader KH. Exposure to ultraviolet-B and risk of developing rheumatoid arthritis among women in the Nurses' Health Study. Ann Rheum Dis. 2013;72:506–511. - PMC - PubMed

[4] Arkema EV, Hart JE, Bertrand KA, Laden F, Grodstein F, Rosner BA, Karlson EW, Costenbader KH. Exposure to ultraviolet-B and risk of developing rheumatoid arthritis among women in the Nurses' Health Study. Ann Rheum Dis. 2013;72:506–511. - PMC - PubMed

[5] Blunden A, Lower T, Slevin T. Knowledge, awareness, and use of the UV index amongst the West Australian public. J Health Commun. 2004;9:207–221. - PubMed

[6] Blunden A, Lower T, Slevin T. Knowledge, awareness, and use of the UV index amongst the West Australian public. J Health Commun. 2004;9:207–221. - PubMed

[7] Boni R, Schuster C, Nehrhoff B, Burg G. Epidemiology of skin cancer. Neuroendocrinol Lett. 2002;23 (Suppl 2:48–51. - PubMed

[8] Boni R, Schuster C, Nehrhoff B, Burg G. Epidemiology of skin cancer. Neuroendocrinol Lett. 2002;23 (Suppl 2:48–51. - PubMed

[9] Brooks KR, Brooks DR, Hufford D, Samenow J, Geller AC. Are television stations and weather pages still reporting the UV index? A national media follow-up study. Arch Dermatol. 2005;141:526. - PubMed

[10] Brooks KR, Brooks DR, Hufford D, Samenow J, Geller AC. Are television stations and weather pages still reporting the UV index? A national media follow-up study. Arch Dermatol. 2005;141:526. - PubMed

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Cumulative ultraviolet radiation flux in adulthood and risk of incident skin cancers in women

Affiliations

Cumulative ultraviolet radiation flux in adulthood and risk of incident skin cancers in women

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Affiliations

Abstract

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