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. 2014 Apr;42(2):436-43.
doi: 10.1177/0300060514521154. Epub 2014 Mar 4.

Absence of association between atherosclerotic cerebral infarction and TNFSF4/TNFRSF4 single nucleotide polymorphisms rs1234313, rs1234314 and rs17568 in a Chinese population

Qing Huang  1 , Qi-Dong Yang, Xing-Lin Tan, Jie Feng, Tao Tang, Jian Xia, Le Zhang, Li Huang, Yong-Ping Bai, Yun-Hai Liu
Affiliations
Free article

Absence of association between atherosclerotic cerebral infarction and TNFSF4/TNFRSF4 single nucleotide polymorphisms rs1234313, rs1234314 and rs17568 in a Chinese population

Qing Huang et al. J Int Med Res. 2014 Apr.
Free article

Abstract

Objective: To clarify the association between atherosclerotic cerebral infarction (ACI) and the single nucleotide polymorphisms (SNP) rs1234313 and rs1234314 (in TNFSF4) and rs17568 (in TNFRSF4).

Methods: Genomic DNA was extracted from peripheral blood of patients with ACI and healthy control subjects. The presence of carotid plaque was determined. Rs1234313, rs1234314 and rs17568 were characterized via SNP genotyping assay and verified by DNA sequencing.

Results: Genotype distributions were in Hardy-Weinberg equilibrium. There were no significant differences in the allele and genotype distributions of rs1234313, rs1234314 and rs17568 between patients with ACI (n = 450) and healthy control subjects (n = 378), or between patients with ACI and carotid plaque (n = 342) and controls.

Conclusions: There were no significant associations between rs1234313, rs1234314 and rs17568 and ACI risk in a Han Chinese population.

Keywords: Atherosclerosis; SNP; TNFRSF4; TNFSF4; cerebral infarction.

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