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Comment
. 2014 Mar;4(3):278-9.
doi: 10.1158/2159-8290.CD-14-0084.

Forecast: rough seas for leukemia

David M Hockenbery  1
Affiliations
Comment

Forecast: rough seas for leukemia

David M Hockenbery. Cancer Discov. 2014 Mar.

Abstract

Expression of BCL-2, BCL-XL, and MCL-1 in acute myelogenous leukemia is highly variable. Cellular BH3 profiling can help decide which are likely to respond to BCL-2-targeted BH3 mimetics.

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  • Selective BCL-2 inhibition by ABT-199 causes on-target cell death in acute myeloid leukemia.
    Pan R, Hogdal LJ, Benito JM, Bucci D, Han L, Borthakur G, Cortes J, DeAngelo DJ, Debose L, Mu H, Döhner H, Gaidzik VI, Galinsky I, Golfman LS, Haferlach T, Harutyunyan KG, Hu J, Leverson JD, Marcucci G, Müschen M, Newman R, Park E, Ruvolo PP, Ruvolo V, Ryan J, Schindela S, Zweidler-McKay P, Stone RM, Kantarjian H, Andreeff M, Konopleva M, Letai AG. Pan R, et al. Cancer Discov. 2014 Mar;4(3):362-75. doi: 10.1158/2159-8290.CD-13-0609. Epub 2013 Dec 17. Cancer Discov. 2014. PMID: 24346116 Free PMC article.

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