Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2013;17(5):450-5.
doi: 10.5114/wo.2013.37543. Epub 2013 Nov 14.

Assessment of general characteristics of patients with primary metastatic breast carcinoma: single center experience

Ummugul Uyeturk  1 , Burcin Budakoglu  2 , Ibrahim Turker  2 , Kaan Helvaci  2 , Ozlem Uysal Sonmez  2 , Gulali Aktas  1 , Ulku Yalcintas Arslan  2 , Omur Berna Cakmak Oksuzoglu  2
Affiliations

Assessment of general characteristics of patients with primary metastatic breast carcinoma: single center experience

Ummugul Uyeturk et al. Contemp Oncol (Pozn). 2013.

Abstract

Introduction: Breast cancer (BC) is a heterogeneous disease. Several subgroups have been identified, according to the clinical presentation and radiographic, pathological, biological, and molecular characteristics of the tumor. Intrinsic genetic heterogeneity may be responsible for these differences. To date, little is known about the clinical features and outcome of patients with primary metastatic BC (PMBC) defined as those presenting with stage IV disease.

Material and methods: Between September 2007 and May 2011, BC patients who were admitted to a clinic were assessed. Patients with PMBC were included in this retrospective analysis. The patients' demographic characteristics, treatment schedules, and survival data were recorded.

Results: Of 2478 BC patients, 102 (4.1%) with PMBC were included in the analysis. The median age of the patients was 50 (26-90) years. Only four patients (3.9%) had previously undergone mammography. The median progression-free survival (PFS) and overall survival (OS) were 30 and 66 months, respectively. The PFS and OS were unaffected by age, menopausal status, ECOG, histology, or tumor grade. Both PFS and OS were affected by HR status (log rank p = 0.006, log rank p = 0.04), HER2 status (p = 0.001, p = 0.005), site of metastasis (p = 0.01, p = 0.04), radiotherapy (p = 0.04, OS p = 0.03), and bisphosphonate treatment (p = 0.02, p = 0.006). PFS was greater in the hormone therapy group (43 months, p = 0.03) while OS was greater in the patients that received chemotherapy (76 months, p = 0.01).

Conclusions: Mammography should be given greater emphasis, considering its importance in the prevention of PMBC. As a treatment option for bone and soft tissue metastatic PMBC patients, hormone therapy should be effective as a first-line treatment.

Keywords: demographic characteristics; factors affecting survival; mammography; primary metastatic breast carcinoma.

PubMed Disclaimer

Figures

Fig. 1
Fig. 1
Kaplan-Meier curve showing the rate of PFS in the patients
Fig. 2
Fig. 2
Kaplan-Meier curve showing the rate of OS in the patients
Fig. 3
Fig. 3
Kaplan-Meier curves showing the rate of PFS by HR and HER2 status
Fig. 4
Fig. 4
Kaplan-Meier curves showing the rate of OS by HR and HER2 status
Fig. 5
Fig. 5
Kaplan-Meier curves showing the rate of PFS by metastasis Region
Fig. 6
Fig. 6
Kaplan-Meier curves showing the rate of OS by metastasis region
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Cardoso F, Harbeck N, Fallowfield L, et al. ESMO Guidelines Working Group Locally recurrent or metastatic breast cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol. 2012;23(Suppl 7):11–19. - PubMed
    1. Ferlay J, Steliarova-Foucher E, Lortet-Tieulent J, et al. Cancer incidence and mortality patterns in Europe: estimates for 40 countries in 2012. Eur J Cancer. 2013;49:1374–1403. - PubMed
    1. Burstein HJ, Schwartz RS. Molecular origins of cancer. N Engl J Med. 2008;358:527. - PubMed
    1. Chang EL, Lo S. Diagnosis and management of central nervous system metastases from breast cancer. Oncologist. 2003;8:398–410. - PubMed
    1. Autier P. Frequency, digital technology, and the efficiency of screening mammography. Ann Intern Med. 2011;155:554–555. - PubMed

LinkOut - more resources