[Structure of the O-specific polysaccharides and the protective activity of the lipopolysaccharides in Pseudomonas aeruginosa of 7 immunotypes (after Fisher)]

Abstract

The structure of O-specific polysaccharides and the protective activity of lipopolysaccharides (LPS) obtained from seven P. aeruginosa immunotypes (according to Fisher's classification) have been studied. The structure of O-specific polysaccharides, immunotypes 2, 3, 4, 5 and 6, is identical to that of polysaccharides of serotypes 011; 0(2a), 2c; 01; 010a, 10b; 07a, 7d respectively. No structural analogs of O-polysaccharide characteristic of immunotypes 1 and 7 have been detected among serotypes classified according to the scheme of Lányi-Bergan-Akatova-Smirnova. The specific character of O-polysaccharides is confirmed by the results of the passive hemagglutination inhibition test, but the data of the passive hemagglutination test indicate that LPS of different immunotypes are antigenically related. As revealed in experiments on the active immunization of mice, LPS of seven immunotypes possess more or less pronounced cross protective properties. The causes of the cross protective activity observed in experiments with these LPS are discussed.