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Comment
. 2014 Mar 18;111(11):3905-6.
doi: 10.1073/pnas.1402020111. Epub 2014 Mar 5.

Transcriptional pausing to scout ahead for DNA damage

Bennett Van Houten  1 , Caroline Kisker
Affiliations
Comment

Transcriptional pausing to scout ahead for DNA damage

Bennett Van Houten et al. Proc Natl Acad Sci U S A. .
No abstract available

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Fig. 1.
Fig. 1.
(A) RNAP stalled at a DNA lesion can be removed by the action of two different helicases. Mfd can push RNAP downstream past the lesion or UvrD/NusA can tow RNAP upstream of the damage site. Recruitment of UvrAB occurs after RNAP is moved, not shown. (B) 1, Mfd senses RNAP pausing and 2, probably dissociates RNAP from the DNA and begins scouting on the transcribed strand (9); 3, once Mfd has encountered a lesion on the transcribed strand a repair-competent complex is formed. The timing of UvrA and UvrB recruitment at the damaged site remains to be determined.
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References

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