Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2014 Feb 15;7(2):416-20.
eCollection 2014.

Value of ABO blood group in predicting the severity of children with Crimean-Congo hemorrhagic fever

Ahmet Sami Güven  1 , Enver Sancakdar  2 , Ali Kaya  1 , Elif Bilge Uysal  3 , Mehmet Burhan Oflaz  1 , Fatih Bolat  1 , Hekim Karapınar  4 , Elif Koç  1 , Füsun Dilara Icagasioglu  1
Affiliations

Value of ABO blood group in predicting the severity of children with Crimean-Congo hemorrhagic fever

Ahmet Sami Güven et al. Int J Clin Exp Med. .

Abstract

Purpose: The aim of this study was to assess the role of ABO blood groups in predicting disease severity and bleeding potential in children with Crimean-Congo hemorrhagic fever (CCHF).

Methods: One hundred fifty-one hospitalized patients with CCHF were enrolled in this retrospective study. The patients were divided according to O- and non-O- (A, B and AB) blood groups (n=91 and n=60, respectively). They were also classified into two groups (severe and non-severe) based on disease severity (n=29 and n=122, respectively). Demographic characteristics, clinical findings, and hematologic and biochemical parameters of all patients were recorded on admission and discharge.

Results: Although, in all cases, compared to the non-O blood group, the ratio of the blood group O was considerably higher (60% vs. 40%) and similarly so in severe cases (58.6% vs. 41.4%), this difference was not statistically significant (p>0.05). The aPTT at discharge and fever duration of the O-blood group were significantly higher than those of the non-O-blood group (p=0.042, p=0.034, respectively). The factor VIII level of the O-blood group was significantly lower than that of the non-O-blood group (p=0.040). Although the ratios of bleeding and severity were higher in the O-blood group compared to the other group, statistical significance was not reached (p>0.05).

Conclusions: Consideration of the ABO blood group is important during diagnostic follow-up to assess the severity of CCHF. In clinical practice, pediatric CCHF patients with the O blood group need to be followed closely for tendency to bleed.

Keywords: CCHF; bleeding; blood groups; children; disease severity.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

References

    1. Whitehouse CA. Crimean-Congo hemorrhagic fever. Antivir Res. 2004;64:144–160. - PubMed
    1. Ergonul O. Crimean-Congo hemorrhagic fever virus: new outbreaks, new discoveries. Curr Opin Virol. 2012;2:215–220. - PubMed
    1. Ergonul O, Celikbas A, Baykam N, Eren S, Dokuzoguz B. Analysis of risk-factors among patients with Crimean-Congo haemorrhagic fever virus infection: severity criteria revisited. Clin Microbiol Infect. 2006;12:551–554. - PubMed
    1. Ergonul O, Celikbas A, Dokuzoguz B, Eren S, Baykam N, Esener H. The characteristics of Crimean-Congo Hemorrhagic Fever in a recent outbreak in Turkey and the impact of oral ribavirin therapy. Clin Infect Dis. 2004;39:285–289. - PubMed
    1. Greenwell P. Blood group antigens: molecules seeking a function? Glycoconj J. 1997;14:159–173. - PubMed

LinkOut - more resources