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. 2012 Spring;1(1):3-5.

Presbyopia: a new potential pharmacological treatment

Jorge Benozzi  1 , Giovanna Benozzi  1 , Betina Orman  2
Affiliations

Presbyopia: a new potential pharmacological treatment

Jorge Benozzi et al. Med Hypothesis Discov Innov Ophthalmol. 2012 Spring.

Abstract

Presbyopia occurs after 40 years of age in humans with a progressive loss of accommodation. Accommodation depends on the contraction of the ciliary muscle and iris, lens changes and convergence. The parasympathetic system regulates the degree of ciliary muscle and iris contraction necessary to modify the shape and position of the lens and its stimulation is effective through the activation of muscarinic receptors that are present in both structures. The hypothesis proposed here suggests the correction of accommodation in emmetropic presbyopic patients using a pharmacological treatment that includes a cholinergic agent combined with non-steroidal anti-inflammatory drugs (NSAIDs). This drug combination can restore near vision without affecting distance vision. It is important to note that the pharmaceutical form used was devoid of any inflammatory or other collateral effects.

Keywords: Accommodation; Pharmacological treatment; Presbyopia.

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Figures

Figure1
Figure1
Near vision accommodation in patients in the pharmacological treatment. Accommodation in near vision in 200 emmetropic eyes of 100 patients treated with (▲ right eye) (▼ left eye) or without (without the drop for 24 hours) or with the combination of pilocarpine and diclofenac (● right eye) (■ left eye), during a 5 year period
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