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Case Reports
. 2014 Jul;41(7):597-601.
doi: 10.1111/cup.12326. Epub 2014 Apr 8.

Ponatinib-induced neutrophilic panniculitis

May Zhang  1 , Khaled M Hassan, Amy Musiek, Ilana S Rosman
Affiliations
Case Reports

Ponatinib-induced neutrophilic panniculitis

May Zhang et al. J Cutan Pathol. 2014 Jul.

Abstract

Ponatinib is a bcr-abl tyrosine-kinase inhibitor (TKI) used to treat resistant and refractory chronic myeloid leukemia and Philadelphia chromosome-positive acute lymphoblastic leukemia that express bcr-abl. Neutrophilic panniculitis has been described in rare cases of patients on other TKIs in the same class as ponatinib. We present the first case of neutrophilic panniculitis following treatment with ponatinib and summarize the other cases of panniculitis caused by TKIs.

Keywords: chronic myeloid leukemia; drug reaction; panniculitis; ponatinib.

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