Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Editorial
. 2014 Mar 6;13(1):34.
doi: 10.1186/1475-2859-13-34.

Yeast biotechnology: teaching the old dog new tricks

Affiliations
Editorial

Yeast biotechnology: teaching the old dog new tricks

Diethard Mattanovich et al. Microb Cell Fact. .

Abstract

Yeasts are regarded as the first microorganisms used by humans to process food and alcoholic beverages. The technology developed out of these ancient processes has been the basis for modern industrial biotechnology. Yeast biotechnology has gained great interest again in the last decades. Joining the potentials of genomics, metabolic engineering, systems and synthetic biology enables the production of numerous valuable products of primary and secondary metabolism, technical enzymes and biopharmaceutical proteins. An overview of emerging and established substrates and products of yeast biotechnology is provided and discussed in the light of the recent literature.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Substrates and products of yeast bioprocesses. Main carbon sources employed in yeast bioprocesses are derived from (A) corn starch, (B) cane or beet sugar, (C) lignocellulose (corn stover, straw, wood etc.) and (D) crude glycerol from biodiesel production. Different native and engineered yeast strains convert the substrate to products of (E) primary or (F) secondary metabolism, or (G) recombinant proteins. Whole cell biocatalysis is a special case where (H) a complex substrate is biochemically transformed to (I) a product by the metabolic activity of yeast cells. Chemical structures are illustrative images only.

References

    1. Internatl. Yeast Co. Ltd. Verfahren zur Herstellung von Hefe nach dem Zulaufverfahren. 1933. German Patent DE583760.
    1. Porro D, Gasser B, Fossati T, Maurer M, Branduardi P, Sauer M, Mattanovich D. Production of recombinant proteins and metabolites in yeasts: when are these systems better than bacterial production systems? Appl Microbiol Biotechnol. 2011;89:939–948. doi: 10.1007/s00253-010-3019-z. - DOI - PubMed
    1. Rozpędowska E, Hellborg L, Ishchuk OP, Orhan F, Galafassi S, Merico A, Woolfit M, Compagno C, Piskur J. Parallel evolution of the make-accumulate-consume strategy in Saccharomyces and Dekkera yeasts. Nat Commun. 2011;2:302. - PMC - PubMed
    1. Toivola A, Yarrow D, van den Bosch E, van Dijken JP, Scheffers WA. Alcoholic fermentation of d-Xylose by yeasts. Appl Environ Microbiol. 1984;47:1221–1223. - PMC - PubMed
    1. Ryabova OB, Chmil OM, Sibirny AA. Xylose and cellobiose fermentation to ethanol by the thermotolerant methylotrophic yeast Hansenula polymorpha. FEMS Yeast Res. 2003;4:157–164. doi: 10.1016/S1567-1356(03)00146-6. - DOI - PubMed

Publication types