Axon guidance: FLRTing promotes attraction
- PMID: 24602885
- DOI: 10.1016/j.cub.2014.01.038
Axon guidance: FLRTing promotes attraction
Abstract
A recent study demonstrates a new mechanism by which crosstalk between multiple guidance cues is integrated during axon pathfinding. FLRT3 is a novel co-receptor for Robo1 that acts as a context-dependent modulator of Netrin-1 attraction in thalamocortical axons.
Copyright © 2014 Elsevier Ltd. All rights reserved.
Comment on
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FLRT3 is a Robo1-interacting protein that determines Netrin-1 attraction in developing axons.Curr Biol. 2014 Mar 3;24(5):494-508. doi: 10.1016/j.cub.2014.01.042. Epub 2014 Feb 20. Curr Biol. 2014. PMID: 24560577
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