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Comment
. 2014 Mar 3;24(5):R206-8.
doi: 10.1016/j.cub.2014.01.027.

Aging: it's SIRTainly possible to restore mitochondrial dysfunction

Brooke E Christian  1 , Gerald S Shadel  2
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Aging: it's SIRTainly possible to restore mitochondrial dysfunction

Brooke E Christian et al. Curr Biol. .
Free article

Abstract

Mitochondrial dysfunction is strongly associated with aging. A recent study shows that reduced nuclear SIRT1 activity initiates age-related mitochondrial decline through a signaling pathway that perturbs expression of genes encoded by mitochondrial DNA. This reversible pathway has potential anti-aging therapeutic value.

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