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Editorial
. 2014;13(7):1057-8.
doi: 10.4161/cc.28379. Epub 2014 Feb 27.

Cardiomyocyte cell cycle: Meis-ing something?

Ahmed I Mahmoud  1 , Diana Canseco  2 , Feng Xiao  2 , Hesham A Sadek  2
Affiliations
Editorial

Cardiomyocyte cell cycle: Meis-ing something?

Ahmed I Mahmoud et al. Cell Cycle. 2014.
No abstract available

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Figures

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Figure 1. The diverse roles of Meis1. In the bone marrow, Meis1 and its cofactors transcriptionally activate Hif-1α and Hif-2α, leading to a reduction in the level of reactive oxygen species and maintenance of hematopoietic stem cells (HSC) quiescence (left panel). In the postnatal heart, Meis1 (and perhaps its cofactors Hoxa10, Hoxa11 and Hoxd12) transcriptionally activates CDKIs, thus contributing to the postnatal cell cycle arest of cardiomyocytes (right panel).
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References

    1. Pasumarthi KB, et al. Circ Res. 2002;90:1044–54. doi: 10.1161/01.RES.0000020201.44772.67. - DOI - PubMed
    1. Senyo SE, et al. Nature. 2013;493:433–6. doi: 10.1038/nature11682. - DOI - PMC - PubMed
    1. Porrello ER, et al. Proc Natl Acad Sci U S A. 2013;110:187–92. doi: 10.1073/pnas.1208863110. - DOI - PMC - PubMed
    1. Mahmoud AI, et al. Nature. 2013;497:249–53. doi: 10.1038/nature12054. - DOI - PMC - PubMed
    1. Pines J. Semin Cancer Biol. 1995;6:63–72. doi: 10.1006/scbi.1995.0009. - DOI - PubMed

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