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. 2014 Mar 6;9(3):e89597.
doi: 10.1371/journal.pone.0089597. eCollection 2014.

Impact of premature ovarian failure on mortality and morbidity among Chinese women

Xiaoyan Wu  1 , Hui Cai  2 , Asha Kallianpur  3 , Honglan Li  4 , Gong Yang  2 , Jing Gao  4 , Yong-Bing Xiang  4 , Bu-Tian Ji  5 , Yu-Tang  4 , Wei Zheng  2 , Xiao-Ou Shu  2
Affiliations

Impact of premature ovarian failure on mortality and morbidity among Chinese women

Xiaoyan Wu et al. PLoS One. .

Abstract

Objective: To evaluate associations of premature ovarian failure (POF) with mortality and morbidity in Asian populations.

Methods: We identified 1,003 cases of POF among 36,402 postmenopausal women who participated in the Shanghai Women's Health Study, a population-based cohort study. Cox regression and logistic regression models were applied in data analysis.

Results: After adjustment for potential confounding factors, we found that POF increased the risk of total and cancer-specific mortality (HR (95%CIs): 1.29 (1.08-1.54) and 1.38 (1.05-1.81), respectively). POF was also associated with high prevalence of autoimmune disease (OR (95%CI): 1.56 (1.04-2.35)) but decreased incidence of breast cancer (OR (95%CI): 0.59 (0.38-0.91)). Similar results were observed when hormone replacement therapy users were excluded from the analysis. POF is associated with high waist-to-hip ratio.

Conclusions: Our results suggest that women with POF experience increased mortality and that these women may benefit from heightened surveillance and appropriate interventions.

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Conflict of interest statement

Competing Interests: The authors have declared that no competing interests exist.

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