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. 2014 Mar 6;10(3):e1003909.
doi: 10.1371/journal.ppat.1003909. eCollection 2014 Mar.

Five things to know about genetically modified (GM) insects for vector control

Luke Alphey  1 , Nina Alphey  2
Affiliations

Five things to know about genetically modified (GM) insects for vector control

Luke Alphey et al. PLoS Pathog. .
No abstract available

PubMed Disclaimer

Conflict of interest statement

I have read the journal's policy and have the following conflicts: LA has employment and equity interest in Oxitec Ltd, and NA has an indirect interest therein. Oxitec is developing genetic control methods for the control of pest insects. Oxitec and the University of Oxford own intellectual property related to the subject matter of this paper. This does not alter our adherence to all PLOS policies on sharing data and materials.

Figures

Figure 1
Figure 1. Creating a new transgenic strain.
(A) DNA is injected into insect eggs; offspring of injection survivors are screened for presence of the marker gene indicating transgene presence. (B) Transposase-mediated transgene insertion.
See this image and copyright information in PMC

References

    1. Alphey L, Benedict MQ, Bellini R, Clark GG, Dame DA, et al. (2010) Sterile-insect methods for control of mosquito-borne diseases: an analysis. Vector Borne Zoonotic Dis 10: 295–311. - PMC - PubMed
    1. Dyck VA, Hendrichs J, Robinson AS,editors (2005) Sterile Insect Technique: Principles and practice in Area-Wide Integrated Pest Management. The Netherlands: Springer. 801 p.
    1. Fraser MJ Jr (2012) Insect Transgenesis: Current Applications and Future Prospects. Annu Rev Entomol 57: 267–289. - PubMed
    1. Nimmo D, Alphey L, Meredith J, Eggleston P (2006) High efficiency site-specific genetic engineering of the mosquito genome. Insect Mol Biol 15: 129–136. - PMC - PubMed
    1. Alphey L (2014) Genetic Control of Mosquitoes. Annu Rev Entomol 59: 205–224. - PubMed

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