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. 1988;114(5):525-7.
doi: 10.1007/BF00391506.

Sudden outbreak of a leukemia-like lesion in female CBA mice after repeated injections of 5-azacytidine

A Luz  1 , A B Murray
Affiliations

Sudden outbreak of a leukemia-like lesion in female CBA mice after repeated injections of 5-azacytidine

A Luz et al. J Cancer Res Clin Oncol. 1988.

Abstract

A total of 11 i.p. injections of 1 mg/kg 5-azacytidine given within 21 weeks induced a sudden outbreak of a leukemia-like disease in female CBA mice about 2 weeks after the last injection. The outbreak of disease was highly synchronous; 68% of animals who had survived the treatment period succumbed within a period of 5 days, 2/3 of them on a single day. The lesion had a characteristic form commonly presenting as a result of hemorrhagic effusion in the thoracic and/or abdominal cavities, associated with diffuse infiltration of lymphatic and fatty tissue by lymphoblasts. It appears that a critical combination of factors was responsible for the unexpected appearance of the lesion. Female BALB/c mice treated identically were not affected. The factors indicating that the lesion was induced by an epigenetic mechanism are discussed.

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