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. 2014 Apr 22;53(17):4377-81.
doi: 10.1002/anie.201311200. Epub 2014 Mar 6.

Dual platinum and pyrrolidine catalysis in the direct alkylation of allylic alcohols: selective synthesis of monoallylation products

Ryozo Shibuya  1 , Lu Lin, Yasuhito Nakahara, Kazushi Mashima, Takashi Ohshima
Affiliations

Dual platinum and pyrrolidine catalysis in the direct alkylation of allylic alcohols: selective synthesis of monoallylation products

Ryozo Shibuya et al. Angew Chem Int Ed Engl. .

Abstract

A dual platinum- and pyrrolidine-catalyzed direct allylic alkylation of allylic alcohols with various active methylene compounds to produce products with high monoallylation selectivity was developed. The use of pyrrolidine and acetic acid was essential, not only for preventing undesirable side reactions, but also for obtaining high monoallylation selectivity.

Keywords: allylic alkylation; homogeneous catalysis; organocatalysis; platinum; pyrrolidine.

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