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Comment
. 2014 Mar 6;53(5):685-7.
doi: 10.1016/j.molcel.2014.02.023.

Chaperoned by prebiotic inorganic polyphosphate molecules: an ancient transcription-independent mechanism to restore protein homeostasis

Harm H Kampinga  1
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Chaperoned by prebiotic inorganic polyphosphate molecules: an ancient transcription-independent mechanism to restore protein homeostasis

Harm H Kampinga. Mol Cell. .
Free article

Abstract

In this issue, Gray et al. (2014) elegantly demonstrate how cells utilize an oxidation-regulated pathway that depletes cellular ATP, lowers proteostatic burden, and leads to accumulation of prebiotic, inorganic polyphosphates with chaperone-like activity for stress protection.

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  • Polyphosphate is a primordial chaperone.
    Gray MJ, Wholey WY, Wagner NO, Cremers CM, Mueller-Schickert A, Hock NT, Krieger AG, Smith EM, Bender RA, Bardwell JC, Jakob U. Gray MJ, et al. Mol Cell. 2014 Mar 6;53(5):689-99. doi: 10.1016/j.molcel.2014.01.012. Epub 2014 Feb 20. Mol Cell. 2014. PMID: 24560923 Free PMC article.

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