Two-back makes step forward in brain imaging genomics

Andrew McIntosh¹, Ian Deary², David J Porteous³

Affiliations

¹ Division of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital, Edinburgh EH10 5HF, UK; Centre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, 7 George Square, Edinburgh EH8 9JZ, UK.
² Centre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, 7 George Square, Edinburgh EH8 9JZ, UK.
³ Centre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, 7 George Square, Edinburgh EH8 9JZ, UK; Centre for Genomic and Experimental Medicine, MRC/University of Edinburgh Institute of Genetics and Molecular Medicine, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, UK. Electronic address: david.porteous@igmm.ed.ac.uk.

PMID: 24607220
DOI: 10.1016/j.neuron.2014.02.023

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Two-back makes step forward in brain imaging genomics

Andrew McIntosh et al. Neuron. 2014.

Free article

. 2014 Mar 5;81(5):959-961.

doi: 10.1016/j.neuron.2014.02.023.

Authors

Andrew McIntosh¹, Ian Deary², David J Porteous³

Affiliations

¹ Division of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital, Edinburgh EH10 5HF, UK; Centre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, 7 George Square, Edinburgh EH8 9JZ, UK.
² Centre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, 7 George Square, Edinburgh EH8 9JZ, UK.
³ Centre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, 7 George Square, Edinburgh EH8 9JZ, UK; Centre for Genomic and Experimental Medicine, MRC/University of Edinburgh Institute of Genetics and Molecular Medicine, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, UK. Electronic address: david.porteous@igmm.ed.ac.uk.

PMID: 24607220
DOI: 10.1016/j.neuron.2014.02.023

Abstract

The combination of brain imaging and genetics promises to identify neural mechanisms underlying complex traits such as cognition and psychiatric disorder. The study by Heck et al. (2014) in this issue of Neuron highlights voltage-gated cation channel activity as a likely link and culprit.

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Converging genetic and functional brain imaging evidence links neuronal excitability to working memory, psychiatric disease, and brain activity.
Heck A, Fastenrath M, Ackermann S, Auschra B, Bickel H, Coynel D, Gschwind L, Jessen F, Kaduszkiewicz H, Maier W, Milnik A, Pentzek M, Riedel-Heller SG, Ripke S, Spalek K, Sullivan P, Vogler C, Wagner M, Weyerer S, Wolfsgruber S, de Quervain DJ, Papassotiropoulos A. Heck A, et al. Neuron. 2014 Mar 5;81(5):1203-1213. doi: 10.1016/j.neuron.2014.01.010. Epub 2014 Feb 13. Neuron. 2014. PMID: 24529980 Free PMC article.

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Two-back makes step forward in brain imaging genomics

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Two-back makes step forward in brain imaging genomics

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