Shaping up to divide: coordinating actin and microtubule cytoskeletal remodelling during mitosis

Abstract

Cell division requires the wholesale reorganization of cell architecture. At the same time as the microtubule network is remodelled to generate a bipolar spindle, animal cells entering mitosis replace their interphase actin cytoskeleton with a contractile mitotic actomyosin cortex that is tightly coupled to the plasma membrane--driving mitotic cell rounding. Here, we consider how these two processes are coordinated to couple chromosome segregation and cell division. In doing so we explore the relative roles of cell shape and the actin cortex in spindle morphogenesis, orientation and positioning.

Keywords: Actin; Cell shape; Cortex; Mitosis; Spindle; Spindle formation; Spindle positioning.