Cohort profile: Mysore parthenon birth cohort

Abstract

The Mysore Parthenon Birth Cohort was established to examine the long-term effects of maternal glucose tolerance and nutritional status on cardiovascular disease risk factors in the offspring. During 1997-98, 830 of 1233 women recruited from the antenatal clinics of the Holdsworth Memorial Hospital (HMH), Mysore, India, underwent an oral glucose tolerance test. Of these, 667 women delivered live babies at HMH. Four babies with major congenital anomalies were excluded, and the remaining 663 were included for further follow-up. The babies had detailed anthropometry at birth and at 6-12-monthly intervals subsequently. Detailed cardiovascular investigations were done at ages 5, 9.5 and 13.5 years in the children, and in the parents at the 5-year and 9.5-year follow-ups. This ongoing study provides extensive data on serial anthropometry and body composition, physiological and biochemical measures, dietary intake, nutritional status, physical activity measures, stress reactivity measures and cognitive function, and socio-demographic parameters for the offspring. Data on anthropometry, cardiovascular risk factors and nutritional status are available for mothers during pregnancy. Anthropometry and risk factor measures are available for both parents at follow-up.

Keywords: Cohort profile; India; children; gestational diabetes; maternal nutrition.

Figure 1.

Flow chart to illustrate the rate of participation and attrition at major follow-up stages of the Parthenon study. HMH: Holdsworth Memorial Hospital.

Figure 2.

Median subscapular skinfold thickness (mm) for offspring of diabetic mothers (ODM), offspring of diabetic fathers (ODF) and controls, aged 0–13.5 years. Continuous lines with black circles, ODM; dashed lines with black squares, ODF; dashed lines with black diamonds, control offspring.