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. 2014 Aug 15;210(4):597-603.
doi: 10.1093/infdis/jiu138. Epub 2014 Mar 8.

Integrating social contact and environmental data in evaluating tuberculosis transmission in a South African township

Jason R Andrews  1 , Carl Morrow  2 , Rochelle P Walensky  1 , Robin Wood  2
Affiliations

Integrating social contact and environmental data in evaluating tuberculosis transmission in a South African township

Jason R Andrews et al. J Infect Dis. .

Abstract

Background: Population models of tuberculosis transmission have not accounted for social contact structure and the role of the environment in which tuberculosis is transmitted.

Methods: We utilized extensions to the Wells-Riley model of tuberculosis transmission, using exhaled carbon dioxide as a tracer gas, to describe transmission patterns in an endemic community. Drawing upon social interaction data and carbon dioxide measurements from a South African township, we created an age-structured model of tuberculosis transmission in households, public transit, schools, and workplaces. We fit the model to local data on latent tuberculosis prevalence by age.

Results: Most tuberculosis infections (84%) were estimated to occur outside of one's own household. Fifty percent of infections among young adults (ages 15-19) occurred in schools, due to high contact rates and poor ventilation. Despite lower numbers of contacts in workplaces, assortative mixing among adults with high rates of smear-positive tuberculosis contributed to transmission in this environment. Households and public transit were important sites of transmission between age groups.

Conclusions: Consistent with molecular epidemiologic estimates, a minority of tuberculosis transmission was estimated to occur within households, which may limit the impact of contact investigations. Further work is needed to investigate the role of schools in tuberculosis transmission.

Keywords: environment; epidemiology; mathematical models; social contacts; tuberculosis.

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Figures

Figure 1.
Figure 1.
Estimated contact-hours between individuals of various age groups in 4 locations (A, own household; B, public transit; C, schools; D, workplaces), with Gaussian smoothing applied to the contour. Abbreviation: HH, household.
Figure 2.
Figure 2.
Modeled (blue line) and observed (red points) latent tuberculosis prevalence by age group, where duration of infectiousness is 12 months and all contacts were recurrent except those in public transit. The gray shaded area reflects 95% credible intervals for model estimates.
Figure 3.
Figure 3.
Estimated proportion of tuberculosis infections acquired in each setting, according to age group. Abbreviation: HH, household.
See this image and copyright information in PMC

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