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. 1988 Aug;32(8):1267-8.
doi: 10.1128/AAC.32.8.1267.

Selective imipenem resistance in Pseudomonas aeruginosa associated with diminished outer membrane permeability

A E Studemeister  1 , J P Quinn
Affiliations

Selective imipenem resistance in Pseudomonas aeruginosa associated with diminished outer membrane permeability

A E Studemeister et al. Antimicrob Agents Chemother. 1988 Aug.

Abstract

The permeability of the outer membranes of imipenem-susceptible and imipenem-resistant clinical isolates of Pseudomonas aeruginosa was investigated by the liposome swelling assay. Sugars and cephaloridine penetrated rapidly, whereas imipenem penetrated poorly into liposomes constructed from porin-rich outer membrane fractions of the resistant isolates.

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References

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