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. 2014 Apr 1;24(7):1802-4.
doi: 10.1016/j.bmcl.2014.02.022. Epub 2014 Feb 22.

Boseongazepines A-C, pyrrolobenzodiazepine derivatives from a Streptomyces sp. 11A057

Mijin Oh  1 , Jae-Hyuk Jang  1 , Soo-Jin Choo  2 , Sun-Ok Kim  3 , Jong Won Kim  2 , Sung-Kyun Ko  2 , Nak-Kyun Soung  3 , Jung-Sook Lee  4 , Chang-Jin Kim  4 , Hyuncheol Oh  5 , Young-Soo Hong  1 , Masashi Ueki  6 , Hiroshi Hirota  6 , Hiroyuki Osada  7 , Bo Yeon Kim  8 , Jong Seog Ahn  9
Affiliations

Boseongazepines A-C, pyrrolobenzodiazepine derivatives from a Streptomyces sp. 11A057

Mijin Oh et al. Bioorg Med Chem Lett. .

Abstract

Three new pyrrolobenzodiazepine derivatives, boseongazepines A-C (1-3), were isolated from a culture broth of Streptomyces sp. 11A057, together with the known compound usabamycin B (4). The structures of 1-4 were determined through the analysis of spectroscopic data including extensive 1D-, 2D-NMR, and MS techniques. Cell growth inhibition effects of these compounds were evaluated against Jurkat, K-562, HL-60, and HepG2 cell lines.

Keywords: Boseongazepines; Cytotoxicity; Pyrrolobenzodiazepine; Streptomyces.

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