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. 2014 Apr 7;20(15):4227-31.
doi: 10.1002/chem.201303989. Epub 2014 Mar 11.

Ruthenium/Imidazolylphosphine catalysis: hydrogenation of aliphatic and aromatic nitriles to form amines

Svenja Werkmeister  1 , Kathrin Junge, Bianca Wendt, Anke Spannenberg, Haijun Jiao, Christoph Bornschein, Matthias Beller
Affiliations

Ruthenium/Imidazolylphosphine catalysis: hydrogenation of aliphatic and aromatic nitriles to form amines

Svenja Werkmeister et al. Chemistry. .

Abstract

A convenient and efficient catalyst system for the hydrogenation of aliphatic nitriles towards the corresponding primary amines in high to excellent yields is presented. In addition, aromatic nitriles are reduced smoothly, too. The use of low catalyst loadings and molecular hydrogen make this protocol an attractive methodology.

Keywords: P,N ligands; amine; hydrogenation; nitrile; ruthenium.

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