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. 1988 Sep;25(1):47-55.
doi: 10.1016/0922-3371(88)90054-8.

A possible maternal-effect mutant of Xenopus laevis: II. Studies of RNA synthesis in dissociated embryonic cells

K Shiokawa  1 , K Tashiro, N Nakakura, Y Fu, Y Atsuchi, S Nakazato, Y Tsuzaki, K Ikenishi
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A possible maternal-effect mutant of Xenopus laevis: II. Studies of RNA synthesis in dissociated embryonic cells

K Shiokawa et al. Cell Differ Dev. 1988 Sep.

Abstract

Embryos from a female of Xenopus laevis (designated as no. 65) arrest development at gastrulation and are assumed to be ova-deficient mutant. We dissociated these embryos and studied RNA synthesis at different stages. The cells from the ova-deficient embryos reaggregated quite actively as wild-type embryo cells until the late gastrula stage. RNA synthesis was normal at the early blastula stage but greatly inhibited by the late blastula (stage 9.5) stage, when the synthesis of DNA and protein was still not inhibited appreciably. Thus, inhibition in RNA synthesis appears to be the first manifestation of the maternal defect that occurs before the gastrulation arrest.

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