Co-stimulatory blockade with belatacept in kidney transplantation

Abstract

Calcineurin inhibitors (CNIs) are the cornerstone of immunosuppression after transplantation but can exert negative effects on chronic allograft function and metabolic profile. Belatacept, a selective co-stimulation blocker of T cells, is the first biologic agent approved for maintenance immunosuppression in kidney transplantation. Studies reveal better preservation of glomerular filtration rate and improved metabolic end points with belatacept when compared to CNIs. Increased incidence of acute rejection is noted with belatacept but overall graft survival looked similar at 5 years. Risk for posttransplant lymphoproliferative disorder is higher in Epstein-Barr virus-seronegative recipients of belatacept. Belatacept seems to be a promising drug, and further experience with its use will define its future role.