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Review
. 2014 Mar;44(3):287-90.
doi: 10.1111/imj.12363.

Hepatosplenic T-cell lymphoma, immunosuppressive agents and biologicals: what are the risks?

K Subramaniam  1 , D Yeung, F Grimpen, J Joseph, K Fay, M Buckland, D Talaulikar, J Elijah, A C Clarke, P Pavli, J Moore
Affiliations
Review

Hepatosplenic T-cell lymphoma, immunosuppressive agents and biologicals: what are the risks?

K Subramaniam et al. Intern Med J. 2014 Mar.

Abstract

We present three cases of the rare hepatosplenic T-cell lymphoma (HSTCL); two patients suffering from Crohn disease who developed HSTCL on azathioprine without exposure to biologicals, and a third patient who had psoriasis treated using etanercept, cyclosporine and methotrexate. The evidence for an association between HSTCL and immunosuppressive drugs and biologicals is reviewed. We argue for improved pharmacovigilance processes to help determine the benefit to risk ratios for the use of these and other new agents.

Keywords: biologicals; hepatosplenic T-cell lymphoma; immunosuppression; inflammatory bowel disease; psoriasis.

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