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Editorial
. 2014;13(8):1211-2.
doi: 10.4161/cc.28381. Epub 2014 Mar 5.

Liver cell reprogramming: parallels with iPSC biology

Kilangsungla Yanger  1 , Ben Z Stanger  1
Affiliations
Editorial

Liver cell reprogramming: parallels with iPSC biology

Kilangsungla Yanger et al. Cell Cycle. 2014.
No abstract available

Keywords: Notch; cholangiocyte; hepatocyte; iPSC; liver; reprogramming; transdifferentiation.

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Figures

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Figure 1.Parallels in the multistep reprogramming process of hepatocytes and induced pluripotent stem cells. Early steps in iPSC generation and hepatocyte reprogramming both involve morphological changes, with cells decreasing in size and the former becoming more rounded. At this stage, gene expression involves downregulation of the starting cell identity (hepatocytes and fibroblasts) and upregulation of early genes expressed by the final cell type (biliary cells and iPSC, respectively). As the reprogramming process continues, additional structural and morphological changes take place along with expression of mature markers. (MET, mesenchymal to epithelial transition).
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References

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