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. 2014 May;52(5):1751-3.
doi: 10.1128/JCM.00469-14. Epub 2014 Mar 12.

Improved detection of bacterial central nervous system infections by use of a broad-range PCR assay

T Meyer  1 , G Franke, S K A Polywka, M Lütgehetmann, J Gbadamosi, T Magnus, M Aepfelbacher
Affiliations

Improved detection of bacterial central nervous system infections by use of a broad-range PCR assay

T Meyer et al. J Clin Microbiol. 2014 May.

Abstract

A universal PCR assay for bacteria and fungi detected meningitis pathogens in 65% of 20 cerebrospinal fluid (CSF) samples from patients with suspected central nervous system (CNS) infections compared to a 35% detection rate by culture and/or microscopy methods. Thus, the PCR assay can improve the diagnosis rate of infective meningitis when standard methods provide a negative result.

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