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. 2014 Mar 12:2014:bau016.
doi: 10.1093/database/bau016. Print 2014.

Expert curation in UniProtKB: a case study on dealing with conflicting and erroneous data

Sylvain Poux  1 , Michele Magrane, Cecilia N Arighi, Alan Bridge, Claire O'Donovan, Kati Laiho; UniProt Consortium
Collaborators, Affiliations

Expert curation in UniProtKB: a case study on dealing with conflicting and erroneous data

Sylvain Poux et al. Database (Oxford). .

Abstract

UniProtKB/Swiss-Prot provides expert curation with information extracted from literature and curator-evaluated computational analysis. As knowledgebases continue to play an increasingly important role in scientific research, a number of studies have evaluated their accuracy and revealed various errors. While some are curation errors, others are the result of incorrect information published in the scientific literature. By taking the example of sirtuin-5, a complex annotation case, we will describe the curation procedure of UniProtKB/Swiss-Prot and detail how we report conflicting information in the database. We will demonstrate the importance of collaboration between resources to ensure curation consistency and the value of contributions from the user community in helping maintain error-free resources. Database URL: www.uniprot.org.

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Figures

Figure 1.
Figure 1.
Screenshot of the general annotation section of the human SIRT5 entry (UniProtKB Q9NXA8, http://www.uniprot.org/uniprot/Q9NXA8).
Figure 2.
Figure 2.
Screenshot of the sequence annotation section of the human SIRT5 entry (UniProtKB Q9NXA8, http://www.uniprot.org/uniprot/Q9NXA8).
Figure 3.
Figure 3.
UniProtKB manual and automatic biocuration processes.
See this image and copyright information in PMC

References

    1. The UniProt Consortium. Activities at the Universal Protein Resource (UniProt) Nucleic Acids Res. 2014;42:D191–D198. - PMC - PubMed
    1. Schnoes AM, Brown SD, Dodevski I, et al. Annotation error in public databases: misannotation of molecular function in enzyme superfamilies. PLoS Comput. Biol. 2009;5:E1000605–E1000605. - PMC - PubMed
    1. Skunca N, Altenhoff A, Dessimoz C. Quality of computationally inferred gene ontology annotations. PLoS Comput. Biol. 2012;8:E1002533–E1002533. - PMC - PubMed
    1. Percudani R, Carnevali D, Puggioni V. Ureidoglycolate hydrolase, amidohydrolase, lyase: how errors in biological databases are incorporated in scientific papers and vice versa. Database. 2013;2013:Bat071. - PMC - PubMed
    1. Nehrt NL, Clark WT, Radivojac P, et al. Testing the ortholog conjecture with comparative functional genomic data from mammals. PLoS Comput. Biol. 2011;7:E1002073–E1002073. - PMC - PubMed

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