Comment on

• Reversible modulation of the activities of both liver microsomal hydroxymethylglutaryl coenzyme A reductase and its inactivating enzyme. Evidence for regulation by phosphorylation-dephosphorylation.

  Ingebritsen TS, Lee HS, Parker RA, Gibson DM. Ingebritsen TS, et al. Biochem Biophys Res Commun. 1978 Apr 28;81(4):1268-77. doi: 10.1016/0006-291x(78)91273-1. Biochem Biophys Res Commun. 1978. PMID: 666819 No abstract available.
• A common bicyclic protein kinase cascade inactivates the regulatory enzymes of fatty acid and cholesterol biosynthesis.

  Carling D, Zammit VA, Hardie DG. Carling D, et al. FEBS Lett. 1987 Nov 2;223(2):217-22. doi: 10.1016/0014-5793(87)80292-2. FEBS Lett. 1987. PMID: 2889619
• Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascade.

  Hawley SA, Boudeau J, Reid JL, Mustard KJ, Udd L, Mäkelä TP, Alessi DR, Hardie DG. Hawley SA, et al. J Biol. 2003;2(4):28. doi: 10.1186/1475-4924-2-28. Epub 2003 Sep 24. J Biol. 2003. PMID: 14511394 Free PMC article.
• LKB1 is the upstream kinase in the AMP-activated protein kinase cascade.

  Woods A, Johnstone SR, Dickerson K, Leiper FC, Fryer LG, Neumann D, Schlattner U, Wallimann T, Carlson M, Carling D. Woods A, et al. Curr Biol. 2003 Nov 11;13(22):2004-8. doi: 10.1016/j.cub.2003.10.031. Curr Biol. 2003. PMID: 14614828
• The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress.

  Shaw RJ, Kosmatka M, Bardeesy N, Hurley RL, Witters LA, DePinho RA, Cantley LC. Shaw RJ, et al. Proc Natl Acad Sci U S A. 2004 Mar 9;101(10):3329-35. doi: 10.1073/pnas.0308061100. Epub 2004 Feb 25. Proc Natl Acad Sci U S A. 2004. PMID: 14985505 Free PMC article.