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. 2014;36(1):25-8.
doi: 10.5581/1516-8484.20140009.

Reticulocyte maturity indices in iron deficiency anemia

Muriel Wollmann  1 , Branca Maria Cerezer Gerzson  2 , Vanessa Schwert  3 , Rafael Weber Figuera  4 , Guilherme de Oliveira Ritzel  4
Affiliations

Reticulocyte maturity indices in iron deficiency anemia

Muriel Wollmann et al. Rev Bras Hematol Hemoter. 2014.

Abstract

Objective: The aim of this study was to analyze the reticulocyte maturity indices (low, medium, and high fluorescence ratios) in iron deficient 1- to 6-year-old children, and identify the prevalence of iron deficiency anemia in this population.

Methods: The present study included 39 subjects, divided into two groups: control subjects (n = 33), and subjects with iron deficiency anemia (n = 6). The results were analyzed by Student's t-test for comparison of means. Differences were considered significant when two-tailed p-value < 0.05.

Results: Subjects with iron deficiency anemia presented increases in the proportion of mean (10.3 ± 4.7% vs. 6.0 ± 3.4%; p-value = 0.003), and high fluorescence reticulocytes (2.3 ± 0.87% vs. 0.9 ± 0.9%; p-value = 0.03) compared to the control group. The prevalence of anemia in this population was 15% (n = 6).

Conclusion: The indices related to immaturity of reticulocytes are higher in the presence of iron deficiency, thus demonstrating a deficiency in the raw material to form hemoglobin and are, therefore, possible early markers of iron deficiency and anemia. We emphasize the need to standardize these indices for use in clinical practice and lab test results.

Keywords: Child; Iron deficiency; Reticulocytes.

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References

    1. Miranda A.S., Franceschini S.C., Priore S.E., Euclydes M.P., Araújo R.M., Ribeiro S.M. Anemia ferropriva e estado nutricional de crianças com idade de 12 a 60 meses do município de Viçosa. MG. Rev Nutr. 2003;16(2):163–169.
    1. Almeida J.L. Prevalência de anemia ferropriva associada a fatores de risco em pré-escolares da creche Coutinho do Fiorello no município de Natividade – RJ. Rev. NewsLab. 2007;84:114–128.
    1. Carvalho M.C., Baracat E.C., Sgarbieri V.C. Anemia ferropriva e anemia de doença crônica: distúrbios do metabolismo de ferro. Segurança alimentar e nutricional. 2006;13(2):54–56.
    1. Mezzomo F., Longo K., Aguiar C., Brandão C.A., Brandão N.M., Spinelli R. Comportamento da reticulometria antes e após a suplementação dietética ferrosa. em crianças com anemia ferropriva. em Erechim-RS. RBAC. 2007;39(2):131–134.
    1. Danise P., Di Palma A., Marchittiello R., Avino D., Atinaldi A., Clemente G. Comparative Study of the Reticulocyte and erythrocyte parameters from the beckman coulter LH750 and Bayer ADVIA 120. ISLH. 2004:13–15.

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