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Comment
. 2014 May-Jun;16(3):413-4.
doi: 10.4103/1008-682X.122868.

Long-term survival of participants in the prostate cancer prevention trial

Jonathan L Silberstein, Oliver Sartor  1
Affiliations
Comment

Long-term survival of participants in the prostate cancer prevention trial

Jonathan L Silberstein et al. Asian J Androl. 2014 May-Jun.

Abstract

The Prostate Cancer Prevention Trial (PCPT) is a seminal study in the field of urology. More than 10 years after its initial publication, updated data from this trial continue to shape our understanding of prostate cancer. Among the major findings from the PCPT has been the demonstration that prostate cancer is common in men with prostate-specific antigen (PSA) once thought to be in the normal range, finasteride prevents the development of benign prostatic hypertrophy, it increases the sensitivity of PSA and digital rectal examination. Furthermore the PCPT helped to establish the link between erectile dysfunction and cardiovascular disease, and perhaps most importantly finasteride demonstrated a 25% relative risk reduction in the diagnosis of prostate cancer compared with placebo.

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  • The influence of finasteride on the development of prostate cancer.
    Thompson IM, Goodman PJ, Tangen CM, Lucia MS, Miller GJ, Ford LG, Lieber MM, Cespedes RD, Atkins JN, Lippman SM, Carlin SM, Ryan A, Szczepanek CM, Crowley JJ, Coltman CA Jr. Thompson IM, et al. N Engl J Med. 2003 Jul 17;349(3):215-24. doi: 10.1056/NEJMoa030660. Epub 2003 Jun 24. N Engl J Med. 2003. PMID: 12824459 Clinical Trial.

References

    1. Thompson IM, Pauler DK, Goodman PJ, Tangen CM, Lucia MS, et al. Prevalence of prostate cancer among men with a prostate-specific antigen level < or = 4.0 ng per milliliter. N Engl J Med. 2004;350:2239–46. - PubMed
    1. Parsons JK, Schenk JM, Arnold KB, Messer K, Till C, et al. Prostate Cancer Prevention Trial, Urologic Diseases in America Project Finasteride reduces the risk of incident clinical benign prostatic hyperplasia. Eur Urol. 2012;62:234–41. - PMC - PubMed
    1. Thompson IM, Chi C, Ankerst DP, Goodman PJ, Tangen CM, et al. Effect of finasteride on the sensitivity of PSA for detecting prostate cancer. J Natl Cancer Inst. 2006;98:1128–33. - PubMed
    1. Thompson IM, Tangen CM, Goodman PJ, Lucia MS, Parnes HL, et al. Finasteride improves the sensitivity of digital rectal examination for prostate cancer detection. J Urol. 2007;177:1749–52. - PubMed
    1. Thompson IM, Tangen CM, Goodman PJ, Lucia MS, Parnes HL, et al. Erectile dysfunction and subsequent cardiovascular disease. JAMA. 2005;294:2996–3002. - PubMed

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