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Comment
. 2014 Mar 13;123(11):1623-4.
doi: 10.1182/blood-2014-01-549683.

Plasma factor XIII: understanding the 99%

Alisa S Wolberg  1
Affiliations
Comment

Plasma factor XIII: understanding the 99%

Alisa S Wolberg. Blood. .

Abstract

In this issue of Blood, Katona et al show that the A and B subunits of plasma factor XIII (pFXIII) bind with substantially tighter affinity than previously thought, and narrow the B subunit residues mediating this interaction to the second sushi domain.

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Conflict of interest statement

Conflict-of-interest disclosure: The author declares no competing financial interests.

Figures

None
FXIII-A2 and FXIII-B2 syntheses occur in cells of bone marrow origin and liver, respectively. The FXIII-A2B2 complex assembles in the plasma, where it subsequently circulates in a complex with fibrinogen.
See this image and copyright information in PMC

Comment on

  • Interaction of factor XIII subunits.
    Katona E, Pénzes K, Csapó A, Fazakas F, Udvardy ML, Bagoly Z, Orosz ZZ, Muszbek L. Katona E, et al. Blood. 2014 Mar 13;123(11):1757-63. doi: 10.1182/blood-2013-10-533596. Epub 2014 Jan 9. Blood. 2014. PMID: 24408323

References

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