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Comment
. 2014 Mar 12;15(3):249-50.
doi: 10.1016/j.chom.2014.02.015.

LINE(1)s of evidence in HBV-driven liver cancer

Mathias Heikenwalder  1 , Ulrike Protzer  2
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LINE(1)s of evidence in HBV-driven liver cancer

Mathias Heikenwalder et al. Cell Host Microbe. .
Free article

Abstract

Hepatitis B virus (HBV) integration in hepatocellular carcinoma (HCC) is a poorly understood event. In a recent Cancer Cell paper, Lau et al. (2014) describe a HBV-human fusion transcript (HBx-LINE1) that functions as a lncRNA, influences the epithelial-mesenchymal transition, and correlates with reduced patient survival and tumor formation in mice.

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