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Comment
. 2014 Apr;22(4):171-3.
doi: 10.1016/j.tim.2014.02.014. Epub 2014 Mar 13.

Loop de loop: viral RNA evades IFIT1 targeting

Justin A Roby  1 , Brian D Clarke  1 , Alexander A Khromykh  2
Affiliations
Comment

Loop de loop: viral RNA evades IFIT1 targeting

Justin A Roby et al. Trends Microbiol. 2014 Apr.

Abstract

In a landmark finding published in Science, Hyde et al. have demonstrated that a hairpin RNA structure adjacent to the 5' cap of alphavirus genomic RNA confers the ability of these viruses to evade restriction by the interferon-induced host protein IFIT1.

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Comment on

  • A viral RNA structural element alters host recognition of nonself RNA.
    Hyde JL, Gardner CL, Kimura T, White JP, Liu G, Trobaugh DW, Huang C, Tonelli M, Paessler S, Takeda K, Klimstra WB, Amarasinghe GK, Diamond MS. Hyde JL, et al. Science. 2014 Feb 14;343(6172):783-7. doi: 10.1126/science.1248465. Epub 2014 Jan 30. Science. 2014. PMID: 24482115 Free PMC article.

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