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. 2014 May;42(5):542-5.
doi: 10.1016/j.ajic.2013.12.009. Epub 2014 Mar 14.

The impact of multidrug resistance on outcomes in ventilator-associated pneumonia

Rudy Tedja  1 , Amy Nowacki  2 , Thomas Fraser  3 , Cynthia Fatica  4 , Lori Griffiths  4 , Steven Gordon  1 , Carlos Isada  1 , David van Duin  5
Affiliations

The impact of multidrug resistance on outcomes in ventilator-associated pneumonia

Rudy Tedja et al. Am J Infect Control. 2014 May.

Abstract

Multidrug-resistant (MDR) organisms in ventilator-associated pneumonia were found in 49 of 107 patients and were associated with home antibiotics, pre-ventilator-associated pneumonia hospital stay, and health care exposure. Overall, MDR organisms were associated with increased mortality (P = .006). On multivariate analysis, MDR status was modulated by organism class. In nonfermenting gram-negative rods, no association between MDR and mortality was found, but, in all other organisms, MDR was associated with increased mortality risk (hazard ratio, 6.15; 95% confidence interval: 1.80-21.05, P = .004).

Keywords: Hospital-acquired infections; Intensive care units; Multidrug-resistant organisms; Pseudomonas aeruginosa.

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