Sugarcoating ER Stress
- PMID: 24630714
- DOI: 10.1016/j.cell.2014.02.035
Sugarcoating ER Stress
Abstract
The hexosamine biosynthetic pathway (HBP) generates metabolites for protein N- and O-glycosylation. Wang et al. and Denzel et al. report a hitherto unknown link between the HBP and stress in the endoplasmic reticulum. These studies establish the HBP as a critical component of the cellular machinery of protein homeostasis.
Copyright © 2014 Elsevier Inc. All rights reserved.
Comment on
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Hexosamine pathway metabolites enhance protein quality control and prolong life.Cell. 2014 Mar 13;156(6):1167-1178. doi: 10.1016/j.cell.2014.01.061. Cell. 2014. PMID: 24630720
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Spliced X-box binding protein 1 couples the unfolded protein response to hexosamine biosynthetic pathway.Cell. 2014 Mar 13;156(6):1179-1192. doi: 10.1016/j.cell.2014.01.014. Cell. 2014. PMID: 24630721 Free PMC article.
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