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Comment
. 2014 Mar 13;156(6):1125-1127.
doi: 10.1016/j.cell.2014.02.035.

Sugarcoating ER Stress

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Sugarcoating ER Stress

Lisa Vincenz et al. Cell. .
Free article

Abstract

The hexosamine biosynthetic pathway (HBP) generates metabolites for protein N- and O-glycosylation. Wang et al. and Denzel et al. report a hitherto unknown link between the HBP and stress in the endoplasmic reticulum. These studies establish the HBP as a critical component of the cellular machinery of protein homeostasis.

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