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Comment
. 2014 Mar 13;156(6):1129-1131.
doi: 10.1016/j.cell.2014.02.037.

Silent mutations make some noise

Siyuan Zheng  1 , Hoon Kim  1 , Roel G W Verhaak  2
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Silent mutations make some noise

Siyuan Zheng et al. Cell. .
Free article

Abstract

Synonymous mutations do not alter amino acids and are generally considered nonfunctional in cancer. Supek et al. now present a compelling analysis suggesting that such silent mutations can be oncogenic by altering transcript splicing and thereby affecting protein function.

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