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. 1989 Feb 1;169(2):585-90.
doi: 10.1084/jem.169.2.585.

A unique antigenic epitope of human melanoma is carried on the common melanoma glycoprotein gp95/p97

K S Furukawa  1 , K Furukawa, F X Real, L J Old, K O Lloyd
Affiliations

A unique antigenic epitope of human melanoma is carried on the common melanoma glycoprotein gp95/p97

K S Furukawa et al. J Exp Med. .

Abstract

Analysis of antibodies present in the serum of melanoma patient FD has shown that they detect a unique tumor epitope present only on the autologous melanoma cell line SK-MEL-131. Previous results had shown that the unique FD epitope is carried on a common glycoprotein of approximately 90 kD, widely expressed on melanoma and a few other cell types. We now show by sequential radioimmunoprecipitation and partial amino acid sequencing that this common molecule is a previously recognized melanoma antigen, originally identified by mouse mAbs, designated gp95 or p97 (and also known as melanotransferrin). Thus, FD is the first of the class I (unique) melanoma antigens that has been characterized and related to a known cell surface molecule.

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References

    1. J Immunol. 1981 Jun;126(6):2408-13 - PubMed
    1. Nature. 1982 Mar 11;296(5853):171-3 - PubMed
    1. J Exp Med. 1984 Oct 1;160(4):1219-33 - PubMed
    1. Proc Natl Acad Sci U S A. 1981 Jan;78(1):539-43 - PubMed
    1. Int J Cancer. 1982 May 15;29(5):511-5 - PubMed

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