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Meta-Analysis
. 2014 Jun;58(12):e148-51.
doi: 10.1093/cid/ciu152. Epub 2014 Mar 14.

Is the interleukin 8 promoter polymorphism rs4073/-251T >A associated with Clostridium difficile infection?

Fabio Miyajima  1 , Andrew Swale  1 , J Eunice Zhang  2 , Ana Alfirevic  2 , Margaret Little  1 , Nicholas J Beeching  3 , Godfrey Smith  4 , Ruwanthi Kolamunnage-Dona  5 , Munir Pirmohamed  1
Affiliations
Meta-Analysis

Is the interleukin 8 promoter polymorphism rs4073/-251T >A associated with Clostridium difficile infection?

Fabio Miyajima et al. Clin Infect Dis. 2014 Jun.

Abstract

The interleukin 8 gene single-nucleotide polymorphism rs4073/-251T >A predisposes to Clostridium difficile infection (CDI), but this association has not been independently validated. In this study, we were unable to replicate this association in either a white cohort or by meta-analysis, suggesting that rs4073/-251T >A is unlikely to constitute a major risk factor for CDI.

Keywords: Clostridium difficile; genetic predisposition; host response; interleukin 8; meta-analysis.

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