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. 1989 Feb;63(2):677-82.
doi: 10.1128/JVI.63.2.677-682.1989.

Inhibition of human T-cell leukemia virus type I replication in primary human T cells that express antisense RNA

T von Rüden  1 , E Gilboa
Affiliations

Inhibition of human T-cell leukemia virus type I replication in primary human T cells that express antisense RNA

T von Rüden et al. J Virol. 1989 Feb.

Abstract

The human T-cell leukemia virus type I is associated with adult T-cell leukemia-lymphoma in humans, a disease which is induced by a malignant transformation of T lymphocytes. Retrovirus vectors carrying human T-cell leukemia virus type I-derived sequences in reversed transcriptional orientation were used to express antisense RNA transcripts in primary human leukocytes. Human T-cell leukemia virus type I replication and virus-mediated immortalization were inhibited in cells harboring antisense constructs. This study suggests that retrovirus-mediated antisense RNA inhibition can be used to protect primary human T-lymphocytes from human T-cell leukemia virus type I-mediated cell transformation.

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