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. 2014 Jan 21;3(2):86-7.
doi: 10.1016/j.molmet.2014.01.003. eCollection 2014 Apr.

From explosives to physiological combustion: Next generation chemical uncouplers

M Jastroch  1 , S Keipert  1 , F Perocchi  2
Affiliations

From explosives to physiological combustion: Next generation chemical uncouplers

M Jastroch et al. Mol Metab. .
No abstract available

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Figures

Figure 1
Figure 1
Mitochondrial uncoupling. (A) Schematic illustration of the mitochondrial inner membrane (IMM) and processes producing and consuming proton motive force. Respiratory chain complexes use the energy of substrate oxidation to pump protons from the matrix to the intermembrane space (IMS) and build up the proton motive force that is normally utilized to drive ATP synthesis . Protons may also leak back to the mitochondrial matrix by either an unregulated basal proton leak or by regulated endogenous proteins such as Uncoupling Proteins (UCPs) and the adenine nucleotide translocase (ANT), . Other uncoupling agents act as weak lipophilic acids or modify uncoupling action of “uncoupling” proteins . By uncoupling, the proton motive force is dissipated as heat instead of being stored in ATP. (B) The graph illustrates the number of publications found in Pubmed with the keywords “mitochondria”, “mitochondrial uncoupling”, and “uncoupling proteins”, over a period of about 100 years. (http://www.ncbi.nlm.nih.gov/pubmed/?term=XX; December 2013). Of note is the increasing interest in mitochondrial uncoupling during the past 10–15 years. (C) In contrast to the interest in “mitochondrial uncoupling”, scientific work using “dinitrophenol” and “FCCP” decreased or stagnated, respectively.
See this image and copyright information in PMC

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